We have 3 very sweet dogs (2 chihuahua mixes, 1 large mixed breed). The oldest is immune suppressed so she can not be boarded and is medicine dependent. It's very easy, but timely (1 hour before breakfast, after breakfast, and before bed). Our other little guy is timid with new people, so need someone patient for him to become comfortable and then he is a total snuggle bug.
We travel often for 4-7 days at a time typically, and prefer to have someone stay at the house with the dogs. They have a dog door, so are really only dependent on the person for meals and medicine, but they love humans to snuggle with and feel safe, so we like to have someone stay overnight. Otherwise the caregiver is welcome to come and go as they please. We like to think we have a comfortable home to enjoy while we are away.